Can we change how our brains age? These scientists think it’s possible

by | Jul 9, 2024 | Climate Change

4 hours agoGetty ImagesIt’s long been known that our lifestyles can help to keep us healthier for longer. Now scientists are asking whether new technology can also help slow down the ageing process of our brains by keeping track of what happens to them as we get older.One sunny morning, 76-year-old Dutch-born Marijke and her husband Tom welcomed me in for breakfast at their home in Loma Linda, an hour east of Los Angeles. Oatmeal, chai seeds, berries, but no processed sugary cereal or coffee were served – a breakfast as pure as Loma Linda’s mission.Loma Linda has been identified as one of the world’s so-called Blue Zones, places where people have lengthier-than-average lifespans. In this case, it is the city’s Seventh-Day Adventist Church community who are living longer.They generally don’t drink alcohol or caffeine, stick to a vegetarian or even vegan diet and consider it a duty of their religion to look after their bodies as best they can. This is their “health message”, as they call it, and it has put them on the map – the city has been the subject of decades of research into why its residents live better for longer.Dr Gary Fraser from the University of Loma Linda told me members of the Seventh-Day Adventist community there can expect not only a longer lifespan, but an increased “healthspan” – that is, time spent in good health – of four to five years extra for women and seven years extra for men.Marijke and Tom had moved to the city later in life, but both were now firmly embedded in the community. There’s no great secret to Loma Linda. Its citizens are simply living a really healthy life, keeping mentally stimulated and valuing the community a religion can often provide.There are regular lectures on healthy living, musical get-togethers and exercise classes.I chatted to Judy, who lives with 112 others at an assisted living facility where there was always the “ability to have heart-opening, brain-opening conversations”, she told me.“What I didn’t realise was how important socialisation is to your brain… without it, it seems to shrink and go away,” Judy said. Science has long recognised the benefits of social interactions and avoiding loneliness. But now it’s also possible to identify whose brains are ageing faster than they should, so they can be tracked and in future potentially be treated better preventatively. As we move towards more personalised, predictive, preventative healthcare models, early diagnosis will be crucial in all areas of health – powered by the incredible possibilities of AI and big data.Computer models that assess how our brains age and predict their decline were shown to me by Andrei Irimia, associate professor of gerontology and computational biology at the University of Southern California.He had created them using MRI scans, data from 15,000 brains and the power of artificial intelligence to understand the trajectory of both brains that are ageing healthily and those in which there is a disease process, such as dementia. “It’s a very sophisticated way to look at patterns that we don’t necessarily know about as humans, but the AI algorithm is able to pick up on them,” he said.Prof Irimia did, of course, take a look inside my head. I’d had a functional MRI scan ahead of my visit and, after analysing its results, Prof Irimia told me I had a brain age eight months older than my chronological age (although apparently the bit that controls talking wasn’t ageing so much. I could have told him that). However, Prof Irimia suggested that the results fall within a two-year error margin.Private companies are starting to commercialise this technology, too. One firm, Brainkey, is offering the service in a variety of clinics around the world. Its founder Owen Philips told me that in future, getting an MRI should become easier.”It’s becoming much more accessible for people to get an MRI scan, and the images coming off them are getting even better and better,” he said. “I don’t mean to nerd out there. But the technology is just getting to a point where we are able to see things much earlier than we could in the past. And that means we can understand exactly what’s happening in an individual patient’s brain. With AI, we can support that.”In contrast to what Prof Irimia’s analysis of my MRI scan had told me, Brainkey’s estimate knocked a year off my brain’s biological age. I was also presented with a 3D-printed model of it, which appeared substantial and, I was assured, was life-sized. The aim here is not just a more precise approach to treatment, but also to be able to quantify how well any interventions are working.Dramatic inc …

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[mwai_chat context=”Let’s have a discussion about this article:nn4 hours agoGetty ImagesIt’s long been known that our lifestyles can help to keep us healthier for longer. Now scientists are asking whether new technology can also help slow down the ageing process of our brains by keeping track of what happens to them as we get older.One sunny morning, 76-year-old Dutch-born Marijke and her husband Tom welcomed me in for breakfast at their home in Loma Linda, an hour east of Los Angeles. Oatmeal, chai seeds, berries, but no processed sugary cereal or coffee were served – a breakfast as pure as Loma Linda’s mission.Loma Linda has been identified as one of the world’s so-called Blue Zones, places where people have lengthier-than-average lifespans. In this case, it is the city’s Seventh-Day Adventist Church community who are living longer.They generally don’t drink alcohol or caffeine, stick to a vegetarian or even vegan diet and consider it a duty of their religion to look after their bodies as best they can. This is their “health message”, as they call it, and it has put them on the map – the city has been the subject of decades of research into why its residents live better for longer.Dr Gary Fraser from the University of Loma Linda told me members of the Seventh-Day Adventist community there can expect not only a longer lifespan, but an increased “healthspan” – that is, time spent in good health – of four to five years extra for women and seven years extra for men.Marijke and Tom had moved to the city later in life, but both were now firmly embedded in the community. There’s no great secret to Loma Linda. Its citizens are simply living a really healthy life, keeping mentally stimulated and valuing the community a religion can often provide.There are regular lectures on healthy living, musical get-togethers and exercise classes.I chatted to Judy, who lives with 112 others at an assisted living facility where there was always the “ability to have heart-opening, brain-opening conversations”, she told me.“What I didn’t realise was how important socialisation is to your brain… without it, it seems to shrink and go away,” Judy said. Science has long recognised the benefits of social interactions and avoiding loneliness. But now it’s also possible to identify whose brains are ageing faster than they should, so they can be tracked and in future potentially be treated better preventatively. As we move towards more personalised, predictive, preventative healthcare models, early diagnosis will be crucial in all areas of health – powered by the incredible possibilities of AI and big data.Computer models that assess how our brains age and predict their decline were shown to me by Andrei Irimia, associate professor of gerontology and computational biology at the University of Southern California.He had created them using MRI scans, data from 15,000 brains and the power of artificial intelligence to understand the trajectory of both brains that are ageing healthily and those in which there is a disease process, such as dementia. “It’s a very sophisticated way to look at patterns that we don’t necessarily know about as humans, but the AI algorithm is able to pick up on them,” he said.Prof Irimia did, of course, take a look inside my head. I’d had a functional MRI scan ahead of my visit and, after analysing its results, Prof Irimia told me I had a brain age eight months older than my chronological age (although apparently the bit that controls talking wasn’t ageing so much. I could have told him that). However, Prof Irimia suggested that the results fall within a two-year error margin.Private companies are starting to commercialise this technology, too. One firm, Brainkey, is offering the service in a variety of clinics around the world. Its founder Owen Philips told me that in future, getting an MRI should become easier.”It’s becoming much more accessible for people to get an MRI scan, and the images coming off them are getting even better and better,” he said. “I don’t mean to nerd out there. But the technology is just getting to a point where we are able to see things much earlier than we could in the past. And that means we can understand exactly what’s happening in an individual patient’s brain. With AI, we can support that.”In contrast to what Prof Irimia’s analysis of my MRI scan had told me, Brainkey’s estimate knocked a year off my brain’s biological age. I was also presented with a 3D-printed model of it, which appeared substantial and, I was assured, was life-sized. The aim here is not just a more precise approach to treatment, but also to be able to quantify how well any interventions are working.Dramatic inc …nnDiscussion:nn” ai_name=”RocketNews AI: ” start_sentence=”Can I tell you more about this article?” text_input_placeholder=”Type ‘Yes'”]
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