History of US-Iran relations: From the 1953 regime change to Trump strikes

by | Jun 23, 2025 | World

EXPLAINERIran remains the US’s adversary in the Middle East since the 1979 Islamic revolution led by Ayatollah Ruhollah Khomeini.
United States-Iran tensions have surged to the highest point in decades after President Donald Trump on Sunday ordered direct strikes that he said “obliterated” key nuclear facilities across the Middle Eastern country.
Iran remains the biggest adversary of the US in the region since the 1979 Islamic revolution led by Ayatollah Ruhollah Khomeini toppled pro-Western Mohammad Reza Pahlavi. Since then, the two nations have sparred over a multitude of issues, including Iran’s nuclear ambitions, Iran’s backing of proxies in the region, and US political interference.
Israel, which has long considered Iran a threat, launched unprecedented strikes across Iran last week after accusing the country of developing nuclear weapons. Israeli claims have not been backed by any credible proof, but Trump dragged the US into the war following the Israeli strikes.
On Sunday, the US directly hit Iran in what the Trump administration called a highly sophisticated covert attack that involved more than 125 US aircraft and 75 precision bombs. Washington said it “devastated” Iran’s nuclear sites, but Tehran has warned it will retaliate.
An IRGC soldier in his sandbag post in Khorramshahr, Iran, after UNSC Resolution 598 and commencement of ceasefire during the Iran-Iraq war [File: Kaveh Kazemi/Getty Images]
Here’s a timeline of US-Iran relations since 1953:

(1953) US-backed coup and reinstallation of the shah: Tensions initially began brewing over the democratically elected Iranian Prime Minister Mohammad Mosaddegh’s …

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