Here are some of the stocks posting the biggest moves in midday trading Wednesday. Palantir Technologies — The defense technology company headed for a sixth consecutive losing day, dropping more than 2% on Wednesday. If Palantir closes in negative territory, that will mark its first six-day losing run since April 2024. Shares have more than doubled in 2025. Medtronic — The medical device company saw shares pop 4% after giving guidance that was better than hoped. For the 2026 fiscal year, the company sees a tariff impact of about $185 million, down from its earlier range of roughly $200 million to $250 million. Medtronic also lifted its non-GAAP guidance for the year to a range of $5.60 to $5.66 per share, up from its earlier call for $5.50 to $5.60 per share and topping the FactSet consensus of $5.55 per share. Avis Budget — Shares of the car rental company slipped 5%. Bank of America downgraded Avis to underperform from buy. “We think that CAR fundamentals and the macro environment don’t support the current stock price which significantly outperformed the market in June,” the firm said. UnitedHealth — The health insurance giant headed for back-to-back losing sessions, dropping more than 2%. Shares have been cooling from last week’s pop, which was driven by news that Warren Buffett’s Berkshire Hathaway revealed a stake …