In this articleNVONVOLLYFollow your favorite stocksCREATE FREE ACCOUNTAfter years of trying to lose weight “the right way,” Jane Zuckerman realized that “putting in the work just wasn’t enough.” Zuckerman, a 32-year-old data analyst based in Washington, D.C., said she lost 90 pounds in college and spent years cycling through nutritionists, therapy and strict routines — only to find herself at her heaviest after the pandemic, at 270 pounds. Zuckerman said GLP-1 injections were out of the question, because she’s afraid of needles. But when the first GLP-1 pill for obesity became available in early January, Zuckerman called her doctor immediately, she said. Almost a month after starting Novo Nordisk’s new Wegovy pill shortly after it launched, she said, she had lost around 11 pounds. Zuckerman is among tens of thousands of patients who drove an explosive demand for prescriptions for Novo’s pill just three months into its launch. Many of them share a common thread: They had long held off on using GLP-1s due to barriers such as high out-of-pocket costs for injections or a fear of needles.That’s one of the earliest takeaways from the rollout: Novo’s pill appears to be expanding the obesity treatment market, largely drawing in new patients rather than converting existing ones from injections. CNBC spoke with five U.S. patients who recently started the pill following its launch, all of whom said they have not previously taken branded GLP-1 injections.But it’s early days for the pill. Many patients have yet to reach higher doses of the drug, and their experiences vary. It will take more time to determine how effective the pill is in supporting patients’ long-term weight loss journeys, whether it helps keep users on GLP-1s for longer than injections do and whether demand for Novo’s product will hold in the face of fresh competition from Eli Lilly. Novo has a head start in the pill arena over Lilly, which just won U.S. approval of its own GLP-1 drug for obesity last week. Analysts previously told CNBC they still expect that rival pill, called Foundayo, to capture a segment of the market, in part because it lacks the dietary restrictions that come with Novo’s oral drug. Still, the Wegovy pill appears to have had the most explosive launch of a GLP-1 product yet. The latest number that Novo disclosed in February is that more than 600,000 prescriptions had been written since its launch, including for more than 3,000 patients in the first week.Analysts at BMO Capital Markets attributed some of the early uptake to an “attractive” entry price of $149 per month and its connection to the well-known Wegovy brand. The pill carries one of the lowest cash prices for a GLP-1 therapy, ranging from $149 to $299 per month, depending on the dose.Even so, the pill’s launch has done little to boost Novo’s stock price, as the Danish drugmaker is struggling to win back market share from Lilly in the broader obesity space and convince investors that its drug pipeline can help it grow beyond its existing products.Novo is expected to report first-quarter sales, which will include the pill for the first time, in May. But sales of the overall Wegovy portfolio are expected to increase from $13.5 billion in 2026 to $18.9 billion in 2031, with the pill contributing $2.76 billion, according to a March GlobalData report. Reaching new patientsThe Wegovy pill is attracting patients with a fear of needles, which is estimated to affect up to 25% of U.S. adults. But the drug is also an alternative for those who have had difficulty accessing branded GLP-1 injections or other medications. “There are a handful of patients that don’t want to be stung by the needle in the case of a vial and syringe, or stung by the price,” Jamey Millar, No …
