Scientists at the University of Cambridge have unveiled a vaccine developed using artificial intelligence that is designed to protect against multiple coronaviruses, including all Covid variants and viruses that could potentially jump from animals to humans and spark future pandemics.
The research team utilized AI to analyze genetic codes from various coronaviruses collected through surveillance programs. The artificial intelligence then created a “super-antigen” capable of training the immune system to recognize and defend against an entire family of viruses, even as they mutate or if new strains emerge. According to researchers, this represents the first instance of an antigen designed by AI being tested in human trials. Initial trials involving 39 people assessed safety, while a planned second study with approximately 200 participants will evaluate how effectively the vaccine stimulates immune responses. Results published in the Journal of Infection indicated the immune system impact was “modest,” though the findings have generated interest among the scientific community.
The Cambridge team is expanding this approach to develop additional vaccines targeting seasonal influenza that would not require annual updates and an H5N1 bird flu vaccine as a precautionary measure. They are also investigating vaccines for viral haemorrhagic fevers, including Ebola. Researchers noted that conventional vaccine development typically begins with a current virus strain, but this AI-driven method aims to stay ahead of viral evolution and potential new outbreaks.
Experts not directly involved in the research have offered qualified support. One scientist noted that artificial intelligence could significantly accelerate vaccine development by predicting immune system responses. Another research director called the results a “pivotal leap forward” in delivering broad viral protection. Government officials characterized the work as a successful application of combining British research expertise with AI technology to develop new treatments.
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