Christina Applegate disclosed on her podcast MeSsy that she does not have multiple sclerosis, reversing a diagnosis she had received in 2021. The 54-year-old actor made the announcement in an episode recorded with fellow actor Jamie-Lynn Sigler and posted to YouTube on Tuesday, expressing her emotional response to learning the diagnosis was incorrect.
Applegate described her reaction upon hearing the news from her doctor, stating she was not relieved by the revelation. She emphasized that despite no longer having an MS diagnosis, her physical symptoms have persisted or worsened, including continued mobility challenges that require wheelchair use. She expressed confusion about her condition and uncertainty regarding what is actually causing her ongoing health issues, noting that doctors will now conduct further investigation to determine what has been happening since 2021.
The actor had become a public figure associated with MS awareness following her 2021 diagnosis, which prompted her to step back from her acting career and retire from her role on the television series Dead to Me. She chronicled her experiences in an emotional memoir published in March. During the podcast episode, both Applegate and Sigler discussed what they characterized as a notable trend of MS misdiagnoses, with Sigler noting that such occurrences are not uncommon. Applegate described the mental challenges of learning she does not have the disease despite experiencing the same symptoms, expressing concern about others questioning whether her experiences were genuine.
Sigler offered reassurance to Applegate, stating that her advocacy work and shared experiences retain their value and meaning regardless of the new diagnostic information. Research referenced during the discussion included a 2024 Swiss-led study published in the Multiple Sclerosis Journal, which documented high rates of both misdiagnosis and underdiagnosis of the condition.
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