Christina Applegate announced on the MeSsY podcast that she was recently found to have been misdiagnosed with multiple sclerosis, reversing an earlier diagnosis she had publicly shared. Despite the change in her medical status, Applegate stated her commitment to remaining an advocate for individuals living with MS.
Applegate first disclosed her MS diagnosis in 2021 and subsequently stepped back from acting work, concluding her role on the Netflix series Dead to Me in 2022. She and co-host Jamie-Lynn Sigler, who was diagnosed with MS in 2001, launched the MeSsY podcast to discuss the disease and related topics. On this week’s episode, Applegate expressed her continued support for the MS community, saying she would “speak out on your behalf forever and ever” despite her changed diagnosis.
Applegate indicated that her health challenges have not improved following the misdiagnosis revelation. She described experiencing significant morning mobility difficulties, noting it takes approximately ten minutes to rise from bed and move to standing, with walking remaining difficult enough that she now uses a walker. She also reported unexplained weight loss and stated she is currently working with her medical team to identify what underlying condition may actually be affecting her health.
Applegate acknowledged that her physical symptoms and appearance have been impacted by these developments, describing visible changes to her facial structure due to weight loss. She emphasized the ongoing nature of her health struggles, indicating that her doctors are conducting investigations to determine what has been occurring since her original 2021 diagnosis.
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