Going to space is harsh on the human body, and as a new study from our research team finds, the brain shifts upward and backward and deforms inside the skull after spaceflight.The extent of these changes was greater for those who spent longer in space. As NASA plans longer space missions, and space travel expands beyond professional astronauts, these findings will become more relevant.Why it mattersOn Earth, gravity constantly pulls fluids in your body and your brain toward the center of the Earth. In space, that force disappears. Body fluids shift toward the head, which gives astronauts a puffy face. Under normal gravity, the brain, cerebrospinal fluid and surrounding tissues reach a stable balance. In microgravity, that balance changes.AdvertisementAdvertisementWithout gravity pulling downward, the brain floats in the skull and experiences various forces from the surrounding soft tissues and the skull itself. Earlier studies showed that the brain appears higher in the skull after spaceflight. But most of those studies focused on average or whole brain measures, which can hide important effects within different areas of the brain.Our goal was to look more closely.[embedded content]How we do our workWe analyzed brain MRI scans from 26 astronauts who spent different lengths of time in space, from a few weeks to over a year. To focus on the brain’s movement, we aligned each person’s skull across scans taken before and after spaceflight.That comparison allowed us to measure how the brain shifted relative to the skull itself. Instead of treating the brain as a single object, we divided it into more than 100 regions and tracked how each one had shifted. This approach enabled us to see patterns that were missed when looking at the whole brain, on average.AdvertisementAdvertisementWe found that the brain consistently moved upward and backward when comparing postflight to preflight. The longer someone stayed in space, the larger the shift. One of the more striking findings came from examining individual brain regions.In astronauts who spent about a year aboard the International Space Station, some areas near the top of the brain moved upward by more than 2 millimeters, while the rest of the brain barely moved. That distance may sound s …
